Which substances most commonly cause fatal overdoses in the U.S. in recent years?

• A. Methamphetamines
• B. Opioids, especially fentanyl, often involved with benzodiazepines and alcohol
• C. Cannabis
• D. Stimulants like meth

Answer: (B)

Opioids are the leading cause of fatal overdoses in the U.S., and within that group, fentanyl is the main driver of recent overdose deaths. Fentanyl is incredibly potent and is often found in counterfeit pills or mixed with heroin, which can catch people off guard and lead to overdose even with small amounts. The risk rises further when opioids are used with other central nervous system depressants like benzodiazepines or alcohol, because these substances amplify respiratory depression and can push a dangerous dose into a fatal range. Cannabis, while not without risks, is associated with very few fatal overdoses, and while methamphetamine and other stimulants contribute to overdose deaths, they do not exceed the level driven by opioids, especially fentanyl, in recent years.